UEFA Champions League Tips | Predictions & Best Bets

Andrew Hendrie:

Expert UEFA Champions League tips as the 2022/23 competition continues with the R16 this week.

UEFA Champions League Tips R16



Match Top Tip Odds 
FC Porto vs Inter BTTS - Yes $1.75
Man City vs Leipzig City Win & BTTS $2.87
Napoli vs Frankfurt Napoli Win To Nil $2.50
Real Madrid vs Liverpool BTTS & Over 2.5 Goals $1.75
Odds correct at time of writing

UEFA Champions League Tips –
Champions League action resumes this week with the last instalment of the R16 second legs. Some mouth-watering showdowns are in prospect, including Man City and RB Leipzig resuming at the Etihad locked at 1-1, while Liverpool head to Real Madrid with a mountain to climb after suffering a 5-2 loss at Anfield in one of the wildest Champions League nights in recent memory. Read on below as our expert football tipsters provide Champions League predictions for selected games every Matchday.

Champions League Predictions This Week

FC Porto vs Inter Predictions

  • Best Bet – BTTS – Yes at $1.75 with bet365

A spot in the quarter-finals is up for grabs as Porto play host to Inter in the second leg of their Champions League tie on Tuesday night. Inter hold the slight 1-0 advantage after Romelu Lukaku struck in the 85th minute in Milan a couple of weeks ago. Both teams have suffered setbacks since that game, with Porto falling at home to Gil Vicente and Inter losing two of their last three games to Bologna and Spezia. Prior to that shock loss to Gil Vicente, Porto had won eight straight games at home, while Inter have now lost two straight on the road. We’re backing an entertaining and open affair, with Porto needing to go for it in order to get back into the tie. Porto have scored in 15 of their last 16 home games, so they should be able to get on the scoresheet, but their defence could be vulnerable as a result, meaning Inter will likely have chances of their own. Backing both teams to find the back of the net in what promises to be a dramatic encounter in Porto.

Man City vs RB Leipzig Predictions

  • Best Bet – City win & BTTS at $2.87 with bet365

Can Man City handle the pressure when RB Leipzig roll into town level at 1-1 with a spot in the Champions League quarter-finals on the line on Tuesday night. City haven’t been at their dominant best this season, but the treble is still on the cards, including an all-important maiden Champions League trophy. City should have really put Leipzig to the sword in the first leg, but they were made to rue a number of missed chances as Josko Gvardiol’s header with 20 minutes remaining saw the spoils shared at 1-1. City are a different beast at home in this competition though – incredibly, they’ve gone unbeaten in 23 home matches in the Champions League, winning 21. Pep Guardiola’s side have also won six straight at the Etihad since a New Year’s Eve draw with Everton. City should win, but they never do things the easy way, which is why we’re also backing Leipzig to get on the scoresheet, with the German club scoring in 23 of their last 24 competitive fixtures.

Napoli vs Eintracht Frankfurt Predictions

  • Best Bet – Napoli Win To Nil at $2.50 with bet365

Frankfurt have enjoyed some incredible nights of European football over the last few years, winning the Europa League last season and reaching the R16 upon their return to the Champions League, but their unlikely run is set to end in emphatic fashion against runaway Serie A leaders Napoli. Frankfurt really needed to use their home ground advantage in the first leg, but things couldn’t have gone any worse, with Napoli scoring two quick-fire first half goals before star striker Randall Kolo Muani was controversially sent off, meaning he will miss the second leg. Napoli have been one of the most impressive sides in Europe all season, with Victor Osimhen and Kvicha Kvaratskheila transforming into two of the best players on the continent. Napoli’s home form has been as dominant as anyone’s this season, while their last six wins in all competitions have come to nil. With Muani out, Frankfurt will struggle to find the back of the net, so another clean sheet beckons for the Italian club.

Real Madrid vs Liverpool Predictions

  • Best Bet – BTTS & Over 2.5 Goals at $1.75 with bet365

After one of the craziest first legs in recent memory, Real Madrid and Liverpool resume hostiles at the Bernabeu on Wednesday night. Liverpool surged to a 2-0 lead at Anfield a couple of weeks ago and looked set for another famous European night, but Real produced one of the most miraculous comebacks in Champions League history, led by Vinicius Jr and Karim Benzema to come away with a 5-2 victory and massive advantage heading into the second leg at home. Liverpool’s season has been ridiculously inconsistent, with Jurgen Klopp’s side thrashing Man United 7-0 before losing 1-0 to last-placed Bournemouth. Liverpool need to go after it from the get-go, which should hopefully ensure an attacking game, but will also leave them open to the counter attack. Given what we saw in the first leg, both teams should be able to find the back of the net – and with Liverpool set to throw everything into the final third, over 2.5 goals also seems likely.

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