US Open 2021 Tips, Daily Picks & Predictions

Andrew Hendrie:
US Open Tips

Novak Djokovic will be aiming to create history by winning the Calendar Year Grand Slam at the 2021 US Open, while another wide open women’s field battles for supremacy in New York, live from Flushing Meadows between August 30 and September 12.

US Open Betting Tips & Predictions

Expert tips, predictions and daily best bets for the US Open, live from Flushing Meadows in New York between August 30 and September 12.

Our daily tips and betting advice will be available when the US Open begins on Monday August 30. Our tennis expert will also have his tips for the outright winners in the days leading up to the tournament.

Who will win the US Open in 2021?

History is on the line for Novak Djokovic as the World No. 1 goes in search of the Calendar Year Grand Slam at the US Open.

The Serbian is seeking to become just the second man in the Open Era behind Australian legend Rod Laver to claim all four major singles title in the same year.

Djokovic has already strolled to Australian Open, Roland Garros and Wimbledon titles in 2021, but his form – for the first time this year – is under question marks after he lost in the Olympics semi-finals and subsequently pulled out of Canada and Cincinnati.

There’s also the added drama of Djokovic returning to Flushing Meadows for the first time since his now infamous default for accidentally striking a lineswoman with a ball last year.

Meanwhile, on the women’s side, Ash Barty will be hoping to back up her Wimbledon triumph with more major glory at the US Open, but the World No. 1 has never been beyond the fourth round in the city that never sleeps.

It’s set to be another wide open women’s major, with the likes of defending champion Naomi Osaka, Simona Halep, Aryna Sabalenka and rising local star Coco Gauff also in contention.

The stage is set for another thrilling fortnight of Grand Slam tennis at the US Open – read on below for all of our tips, best bets and predictions for the tournament.

Today’s Best US Open Picks


Andrey Rublev to beat Ivo Karlovic & over 30.5 games at $1.95 ✅
Sloane Stephens to beat Madison Keys at $2.00 ✅
Thiago Monteiro +6.5 vs Dan Evans & Over 34.5 games at $2.20 ❌
Henri Laaksonen to beat John Millman at $2.69 ✅
Daria Kasatkina to beat Marketa Vondrousova at $2.00 ✅
Henri Laaksonen to beat Cristian Garin at $2.62 ✅
Carlos Alcaraz to beat Arthur Rinderknech, Andrey Rublev to beat Pedro Martinez 3-0 & Stefanos Tsitsipas to beat Adrian Mannarino at $1.98 ❌
Halep to beat Kucova, Azarenka to beat Paolini, Mertens to beat Grammatikopoulou, Svitolina to beat Masarova & Kerber to beat Kalinina at $1.94 ✅
Jordan Thompson to beat Aslan Karatsev at $3.20 ❌ (Thompson led by two sets & had 2 match points)
Bianca Andreescu vs Lauren Davis – Match to go three sets at $3.00 ❌
Elina Svitolina to beat Daria Kasatkina in straight sets at $2.20 ✅
Van De Zandschulp to beat Bagnis & Evans to beat Popyrin at $2.63 ✅
Diego Schwartzman to beat Botic Van De Zandschulp in straight sets at $2.37 ❌
Simona Halep to beat Elina Svitolina at $1.95 ❌
Reilly Opelka to win first set 7-6 over Lloyd Harris at $3.75 ✅
Bianca Andreescu to beat Maria Sakkari at $2.30 ❌
Alexander Zverev to beat Lloyd Harris in straight sets at $2.05 ✅
Belinda Bencic to beat Emma Raducanu at $1.72 ❌
Aryna Sabalenka to beat Leylah Fernandez in straight sets at $1.80 ❌
Novak Djokovic to beat Alexander Zverev and both players to win a set at $2.50

Djokovic vs Medvedev US Open Final Tips, Prediction & Preview

Novak Djokovic to beat Daniil Medvedev and both players to win a set at $2.50 with bet365

History is on the line for Djokovic as he bids to become just the second man in the Open Era to win the Calendar Year Grand Slam, while a victory over Medvedev will see the Serbian overtake Rafael Nadal and Roger Federer for most major singles titles with 21.

Djokovic hasn’t been at his absolute best this US Open – in fact, he’s dropped a set in five matches and lost the opener four times in a row against Kei Nishikori, Jenson Brooksby, Matteo Berrettini and Alexander Zverev.

The World No. 1 was stretched to five sets by Zverev in the semi-finals, but he lifted when it mattered most at the start of the fifth and raced away to a 5-0 lead before closing it out 6-3.

We expect a similar sort of match in the final.

Medvedev has been in great form since the Olympics, registering a 14-1 record that included picking up the Toronto Masters title.

The Russian has defeated Djokovic three times in his career and is perhaps the only player in the world that can hang with the Serbian in extended baseline exchanges.

That’s the good news for Medvedev – the bad news is that he was crushed in straight sets in the Australian Open final earlier this season. If Djokovic plays his best, nobody stands a chance.

However, Djokovic isn’t playing his best and we think Medvedev can take a set – maybe even two. But like he’s done in all his matches so far in New York, Djokovic will likely step up when he needs to.

Four of the last six meetings between the pair have seen both players win a set, but when push comes to shove – and with so much history beckoning – it’s Djokovic who will stand tall and secure a record-breaking 21st major title – and the Grand Slam.

US Open Multi Tips

Check back here daily as our tennis expert releases his best multi tips for the US Open. We will list our ‘Best Multi’ on this page, while you can view our other value multi selections at our dedicated tennis multi tips page.

US Open Seeds

Men’s singles

  • 1. Novak Djokovic
  • 2. Daniil Medvedev
  • 3. Stefanos Tsitsipas
  • 4. Alexander Zverev
  • 5. Andrey Rublev
  • 6. Matteo Berrettini
  • 7. Denis Shapovalov
  • 8. Casper Ruud
  • 9. Pablo Carreno Busta
  • 10. Hubert Hurkacz
  • 11. Diego Schwartzman
  • 12. Jannik Sinner
  • 13. Felix Auger-Aliassime
  • 14. Alex de Minaur
  • 15. Cristian Garin
  • 16. Grigor Dimitrov
  • 17. Gael Monfils
  • 18. Roberto Bautista Agut
  • 19. Aslan Karatsev
  • 20. John Isner
  • 21. Reilly Opelka
  • 22. Lorenzo Sonego
  • 23. Ugo Humbert
  • 24. Dan Evans
  • 25. Karen Khachanov
  • 26. Cam Norrie
  • 27. David Goffin
  • 28. Fabio Fognini
  • 29. Alejandro Davidovich Fokina
  • 30. Marin Cilic
  • 31. Alexander Bublik
  • 32. Filip Krajinovic

Women’s singles

  • 1. Ashleigh Barty
  • 2. Naomi Osaka
  • 3. Aryna Sabalenka
  • 4. Elina Svitolina
  • 5. Karolina Pliskova
  • 6. Iga Swiatek
  • 7. Bianca Andreescu
  • 8. Garbine Muguruza
  • 9. Barbora Krejcikova
  • 10. Belinda Bencic
  • 11. Petra Kvitova
  • 12. Simona Halep
  • 13. Jennifer Brady
  • 14. Victoria Azarenka
  • 15. Elise Mertens
  • 16. Maria Sakkari
  • 17. Anastasia Pavlyuchenkova
  • 18. Elena Rybakina
  • 19. Angelique Kerber
  • 20. Ons Jabeur
  • 21. Karolina Muchova
  • 22. Coco Gauff
  • 23. Madison Keys
  • 24. Daria Kasatkina
  • 25. Danielle Collins
  • 26. Anett Kontaveit
  • 27. Jessica Pegula
  • 28. Paula Badosa
  • 29. Jelena Ostapenko
  • 30. Veronika Kudermetova
  • 31. Petra Martic
  • 32. Yulia Putintseva

US Open Tips & Predictions (men)

Who will win the men’s US Open in 2021?

History is on the line for Novak Djokovic at the 2021 US Open.

The World No. 1 is bidding to become the first man to win all four major singles titles in the same season since Rod Laver in 1969, while he is also gunning for his 21st Grand Slam title, which would elevate him past both Roger Federer and Rafael Nadal on the all-time list.

With Federer and Nadal both sidelined through injury, Djokovic is once again the overwhelming favourite to emerge triumphant – just as he was at the three previous slams in 2021, where he triumphed at the Australian Open, French Open and Wimbledon.

It’s almost impossible to back against Djokovic in a Grand Slam in the current landscape of men’s tennis.

Nobody from the ‘Next Gen’ has proven they can take out Djokovic in this format – and it took the Serbian to eliminate himself from last year’s US Open.

Even though Djokovic stumbled in Tokyo, losing in the semi-finals to Alexander Zverev and going down in the bronze medal match to Pablo Carreno Busta, the reality is that the Olympics are nowhere near as prestigious as a Grand Slam – and with what Djokovic has on the line in New York, it’s understandable he perhaps didn’t give it his all.

We can only see two men potentially stopping Djokovic in New York.

Zverev did it at the Olympics and he’s continued his outstanding form, winning the Cincinnati Masters to arrive at the US Open on an 11-match winning streak.

The German took out two of his main rivals in Cincinnati in Stefanos Tsitsipas and Andrey Rublev, while he was just a couple of points away from winning the US Open last year, going down in a fifth-set tiebreak to Dominic Thiem, who is also absent from this year’s tournament.

Daniil Medvedev is the other man who can seriously challenge Djokovic. The Russian made the US Open final two years ago in a scintillating run which culminated in a five-set loss to Nadal, while he’s taken his game from strength to strength ever since.

Medvedev is 28-5 on hardcourt this season and has won 11 of his 12 titles on the surface. He’s coming off a victory at the Canada Masters and has defeated Djokovic in two of the last four meetings between the pair on hardcourt.

Tsitsipas can’t be ruled out after stretching Djokovic to five sets in the US Open final, but the Greek hasn’t been operating at his best level over the last couple of months – and it will be even tougher for him to conquer the Serbian on hardcourt.

Djokovic is the man to beat, Zverev and Medvedev are next in line, while dark horses to watch include Wimbledon runner-up Matteo Berrettini, the consistent Andrey Rublev and former semi-finalist and Olympics bronze medalist Pablo Carreno Busta.

US Open Tips & Predictions (women)

Who will win the women’s US Open 2021?

Unlike the men’s field, the women’s draw at the US Open is completely wide open, with around 20 players all having genuine chances of lifting the trophy.

World No. 1 Ash Barty is certainly the most consistent and reliable of the top players in the women’s game at the moment – and that’s reflected by her long-standing status on top of the rankings.

Barty captured her second Grand Slam title at Wimbledon with victories over Angelique Kerber and Karolina Pliskova in the semi-finals and final, while she also conquered French Open champion Barbora Krejcikova earlier in the tournament.

Perhaps expectedly, Barty was knocked out in the opening round of the Olympics by Sara Sorribes Tormo, but the Aussie bounced back strongly to win the title in Cincinnati last week without dropping a single set, which included more wins over Krejcikova and Kerber.

Barty has defeated seven top 10 players this year (the most out of any player) and has eight titles on hardcourt. She hasn’t been beyond the fourth round at the US Open, but she’s entering this year’s tournament in her strongest form yet.

One player that represents great value is Kerber, who of course won the 2016 US Open by beating Pliskova in the final.

Kerber has put together a resurgent last couple of months, reaching the Wimbledon and Cincinnati semi-finals – and as mentioned, it took Barty on both occasions to stop her. The German has the experience having captured three major titles and appears to have regained her best form.

If someone else can take out Barty, Kerber will like her chances of going all the way.

Defending champion Naomi Osaka obviously deserves a mention, but she’s had a turbulent year since winning the Australian Open, failing to beat a top 10 player and spending a ton of time on the sidelines after admitting to suffering from mental health issues.

It doesn’t look like Osaka is in the right head space to go all the way and defend her title, but she certainly can’t be discounted.

Belinda Bencic is someone to watch. The Swiss has seemingly been around forever, but she’s still only 24 years of age and could be about to hit her prime after dealing with a lot of injuries over the years.

Bencic is coming off an Olympics gold medal in Tokyo and a quarter-final showing in Cincinnati, while she’s also a former semi-finalist at the US Open. She’s definitely in the top five contenders on current form in our book.

Coco Gauff, the American teenage sensation, has also been flirting with a Grand Slam breakthrough for the last couple of years and what better way to do it than in front of her home fans?

Then there’s the usual suspects such as Simona Halep, Garbine Muguruza, Karolina Pliskova, Elina Svitolina and Petra Kvitova, while American hopes Madison Keys and Sloane Stephens – who squared off in the 2017 final – also play their best tennis at Flushing Meadows.

Overall, Barty is the deserved favourite and by far the most consistent and reliable player in the draw, while Bencic and Kerber have the form and value on their side.